Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21273360 | 0.81 | MAPT (0.38) | TDP1MEN1KMT2APOLBLMNA | |
| SCHEMBL30448079 | 0.81 | MAPT (0.38) | TDP1MEN1KMT2APOLBLMNA | |
| SCHEMBL30410440 | 0.78 | TDP1 (0.50) | TDP1MEN1KMT2APOLBLMNA | |
| SCHEMBL618730 | 0.78 | TDP1 (0.50) | TDP1MEN1KMT2APOLBLMNA | |
| SCHEMBL29176019 | 0.77 | TDP1 (0.39) | TDP1ATMHTR2AHTR2CHTR2B | |
| SCHEMBL31500757 | 0.72 | L3MBTL1 (0.36) | ATMMEN1KMT2ALMNAMAPT | |
| SCHEMBL21273356 | 0.72 | ALDH1A1 (0.44) | TDP1MEN1KMT2APOLBHTT | |
| SCHEMBL20015374 | 0.71 | CCR4 (0.39) | MEN1KMT2ACCR4MAPTNPSR1 | |
| SCHEMBL10596779 | 0.71 | HPRT1 (0.46) | TDP1MEN1KMT2APOLBLMNA | |
| SCHEMBL2521727 | 0.71 | MEN1 (0.48) | ATMMEN1KMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |