Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30448079 | 1.00 | MAPT (0.38) | MAPTLMNAHTTKDM4ENPSR1 | |
| SCHEMBL23536385 | 0.81 | TDP1 (0.43) | MAPTLMNAHTTKDM4ENPSR1 | |
| SCHEMBL31339761 | 0.81 | HTT (0.40) | MAPTLMNAHTTKDM4ENPSR1 | |
| SCHEMBL25428025 | 0.81 | CREBBP (0.35) | MAPTLMNAHTTKDM4ENPSR1 | |
| SCHEMBL25431550 | 0.78 | GLS (0.36) | LMNAHTTCREBBPALDH1A1L3MBTL1 | |
| SCHEMBL31339790 | 0.78 | GLS (0.36) | LMNAHTTCREBBPALDH1A1L3MBTL1 | |
| SCHEMBL31500757 | 0.78 | L3MBTL1 (0.36) | MAPTLMNAKDM4ENPSR1MEN1 | |
| SCHEMBL30410440 | 0.78 | TDP1 (0.50) | MAPTLMNAHTTKDM4ECREBBP | |
| SCHEMBL618730 | 0.78 | TDP1 (0.50) | MAPTLMNAHTTKDM4ECREBBP | |
| SCHEMBL31479973 | 0.77 | MAPT (0.36) | MAPTLMNAHTTCREBBPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745388-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-18 | — | — | US | disclosed |
| US-10745388-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190256500-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
| US-20190256500-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745388-B2 | Indazole compounds and uses thereof | PDXK, PPIP5K2, PCK1 | MAPT 3880/4885LMNA 2392/4885HTT 2736/4885 |
| US-20190256500-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | PDXK, PPIP5K2, PCK1 | MAPT 3880/4885LMNA 2392/4885HTT 2736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.