Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337511 | 0.79 | CHRM2 (0.53) | HTR6ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11786609 | 0.76 | HTR6 (0.54) | HTR6ALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL12073915 | 0.75 | HDAC8 (0.51) | HTR6POLBHTTCREBBPKDM4E | |
| Hydrochloric Acid SCHEMBL11844003 | 0.74 | HTR6 (0.52) | HTR6ALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL28582365 | 0.72 | HTT (0.51) | POLBHTTALDH1A1SMN1; SMN2CREBBP | |
| SCHEMBL1333179 | 0.72 | HTT (0.54) | POLBHTTALDH1A1SMN1; SMN2CREBBP | |
| SCHEMBL887129 | 0.72 | HTT (0.54) | POLBHTTALDH1A1SMN1; SMN2CREBBP | |
| SCHEMBL887130 | 0.72 | CREBBP (0.55) | POLBHTTALDH1A1SMN1; SMN2CREBBP | |
| SCHEMBL4207590 | 0.70 | CREBBP (0.63) | POLBHTTALDH1A1SMN1; SMN2CREBBP | |
| SCHEMBL13806317 | 0.70 | POLB (0.54) | POLBHTTALDH1A1SMN1; SMN2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |