Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932053 | 1.00 | RPS6KB1 (0.45) | RPS6KB1ALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL23536606 | 0.80 | POLB (0.45) | ALDH1A1MAPK1LMNAMAPTPOLB | |
| SCHEMBL29932044 | 0.80 | POLB (0.45) | ALDH1A1MAPK1LMNAMAPTPOLB | |
| SCHEMBL23536369 | 0.79 | ALDH1A1 (0.38) | RPS6KB1ALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL29932151 | 0.73 | KMT2A (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2PHGDH | |
| SCHEMBL952179 | 0.72 | EBP (0.42) | ALDH1A1MAPK1L3MBTL1LMNAMAPT | |
| SCHEMBL952180 | 0.72 | EBP (0.42) | ALDH1A1MAPK1L3MBTL1LMNAMAPT | |
| SCHEMBL8275465 | 0.70 | POLB (0.65) | ALDH1A1L3MBTL1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL23536198 | 0.68 | GRM2 (0.40) | ALDH1A1LMNAPOLBDRD4GRM2 | |
| SCHEMBL23536434 | 0.67 | DRD4 (0.47) | ALDH1A1MAPK1LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |