Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2377873 | 0.83 | CXCR2 (0.37) | CXCR2ALDH1A1NPC1RAB9ALIPG | |
| SCHEMBL23526428 | 0.83 | USP30 (0.40) | CXCR2RIPK1 | |
| SCHEMBL29799702 | 0.82 | PTGDR2 (0.40) | CXCR2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL27186377 | 0.82 | PTGDR2 (0.40) | CXCR2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL23526249 | 0.82 | LPL (0.40) | CXCR2KDM4EALDH1A1LIPGLPL | |
| SCHEMBL4158920 | 0.79 | AKR1B1 (0.46) | CXCR2KDM4ELIPGLPLP4HB | |
| SCHEMBL23526395 | 0.79 | ALDH1A1 (0.38) | CXCR2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL25842706 | 0.78 | LPL (0.37) | CXCR2LIPGLPLROCK1 | |
| SCHEMBL534958 | 0.78 | NPSR1 (0.39) | CXCR2LIPGLPLKMT2AMEN1 | |
| SCHEMBL902458 | 0.77 | LIPG (0.49) | CXCR2ALDH1A1LIPGLPLP4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |