Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 3/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25628754 | 0.85 | CYP1A2 (0.39) | VNN1CYP2D6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1315531 | 0.83 | CYP2D6 (0.35) | VNN1CYP2D6CYP46A1ALDH1A1CYP1A2 | |
| SCHEMBL22605433 | 0.83 | OPRM1 (0.41) | VNN1ALDH1A1CYP1A2OPRM1MEN1 | |
| SCHEMBL6697462 | 0.82 | L3MBTL1 (0.33) | VNN1CYP2D6CYP46A1ALDH1A1OPRM1 | |
| SCHEMBL5974563 | 0.80 | USP2 (0.34) | VNN1CYP2D6CYP46A1ALDH1A1CYP1A2 | |
| SCHEMBL18040925 | 0.79 | JAK2 (0.35) | CYP2D6CYP46A1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27746269 | 0.79 | CYP46A1 (0.30) | CYP46A1 | |
| SCHEMBL28122499 | 0.78 | CYP2D6 (0.34) | VNN1CYP2D6CYP46A1ALDH1A1CYP1A2 | |
| SCHEMBL2943334 | 0.78 | USP2 (0.47) | USP2 | |
| SCHEMBL3163627 | 0.78 | ALDH1A1 (0.34) | CYP2D6ALDH1A1CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |