Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536124 | 0.87 | TSHR (0.39) | KMT2AALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL29931867 | 0.87 | TSHR (0.39) | KMT2AALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL23536363 | 0.85 | MCOLN2 (0.48) | KMT2AMAPTALDH1A1CRHBPCRHR2 | |
| SCHEMBL23536136 | 0.84 | TSHR (0.38) | KMT2AMAPTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL29932103 | 0.84 | TSHR (0.38) | KMT2AMAPTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL23536003 | 0.84 | GPR55 (0.38) | KMT2AALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL29931921 | 0.82 | POLB (0.41) | KMT2AALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL23536117 | 0.82 | POLB (0.41) | KMT2AALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL23535959 | 0.82 | SMN1; SMN2 (0.42) | KMT2AMAPTALDH1A1CRHBPCRHR2 | |
| SCHEMBL29948492 | 0.82 | SMN1; SMN2 (0.42) | KMT2AMAPTALDH1A1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |