Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298438 | 0.84 | PDCD1 (0.47) | GABRA1GABRB2MEN1KMT2ACYP1A2 | |
| SCHEMBL9331821 | 0.83 | GABRA1 (0.41) | GABRA1GABRB2CTSBMEN1KMT2A | |
| SCHEMBL3367748 | 0.82 | GABRA1 (0.45) | GABRA1GABRB2CTSBMEN1KMT2A | |
| SCHEMBL2024322 | 0.80 | CTSB (0.53) | GABRA1GABRB2CTSBMEN1KMT2A | |
| SCHEMBL11630690 | 0.80 | P2RY4 (0.39) | GABRA1GABRB2CTSBMEN1KMT2A | |
| SCHEMBL23664858 | 0.80 | P2RX7 (0.37) | GABRA1GABRB2MEN1KMT2ACYP1A2 | |
| SCHEMBL23665020 | 0.78 | GABRA1 (0.40) | GABRA1GABRB2CTSBMEN1KMT2A | |
| SCHEMBL599099 | 0.77 | GABRA1 (0.57) | GABRA1GABRB2CYP3A4L3MBTL1TP53 | |
| SCHEMBL29604136 | 0.76 | KEAP1 (0.50) | KMT2ACYP1A2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3796970 | 0.76 | KEAP1 (0.50) | KMT2ACYP1A2L3MBTL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021143693-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 苏州泽璟生物制药股份有限公司 | 2021-07-22 | — | — | WO | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |