Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11583456 | 0.98 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2CA2TDP1 | |
| SCHEMBL19838289 | 0.88 | NFKB1 (0.56) | NPC1RAB9ASMN1; SMN2CA2TDP1 | |
| SCHEMBL11583452 | 0.87 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2CA2DYRK1A | |
| SCHEMBL23536449 | 0.84 | PIK3CA (0.47) | NPC1RAB9ASMN1; SMN2CA2KDM4E | |
| SCHEMBL92033 | 0.82 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2CA2TDP1 | |
| SCHEMBL1105986 | 0.79 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TDP1KDM4E | |
| Hydrochloric Acid SCHEMBL11596610 | 0.78 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2CA2TDP1 | |
| SCHEMBL9262651 | 0.76 | DYRK1A (0.50) | CA2DYRK1AILKPOLBGFER | |
| SCHEMBL1748164 | 0.76 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2CA2HDAC6 | |
| Hydrochloric Acid SCHEMBL11147127 | 0.76 | CA2 (0.47) | NPC1RAB9ACA2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076520-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |