SCHEMBL2354294

SCHEMBL2354294

CCOC(=O)CCc1cc(F)c(OCc2cccc(Oc3ccc(C)cc3)c2)c(F)c1

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 14/20 0.61
FFAR4 Q5NUL3 3/20 0.51
THRA P10827 3/20 0.44
THRB P10828 3/20 0.44
GPR34 Q9UPC5 1/20 0.44
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2350121 0.94 FFAR1 (0.53) FFAR1FFAR4THRATHRBGPR34
SCHEMBL2350368 0.94 FFAR1 (0.56) FFAR1FFAR4THRATHRBGPR34
SCHEMBL2350355 0.93 FFAR1 (0.52) FFAR1FFAR4THRATHRB
SCHEMBL2354216 0.92 FFAR1 (0.51) FFAR1FFAR4THRATHRBPPARG
SCHEMBL2354826 0.91 FFAR1 (0.50) FFAR1FFAR4
SCHEMBL2350861 0.89 FFAR1 (0.76) FFAR1FFAR4THRATHRB
SCHEMBL12394621 0.89 FFAR1 (0.64) FFAR1FFAR4THRATHRB
SCHEMBL2351981 0.88 PPARG (0.46) FFAR1FFAR4THRATHRBPPARG
SCHEMBL2346125 0.88 FFAR1 (0.59) FFAR1FFAR4GPR34
SCHEMBL2350395 0.87 FFAR1 (0.50) FFAR1THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8008525-B2 For the 14273 peroxisome proliferator activated receptor; antidiabetic agents, hyperlipidemia, obesity or anorexia; receptor binding assay; drug screening kits TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-08-30 US disclosed
US-20080167378-A1 Receptor Function Regulation Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-10 US disclosed
EP-1688138-A1 RECEPTOR FUNCTION REGULATING AGENT Takeda Pharmaceutical Company Limited (JP) 2006-08-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080167378-A1 Receptor Function Regulation Agent GPR119, INSR, GPR88 FFAR1 16/4885FFAR4 17/4885THRA 68/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.