Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 6/20 | 0.36 |
| ▸ | NOS1 | P29475 | 5/20 | 0.36 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7851163 | 0.79 | PI4KA (0.49) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL3054572 | 0.79 | METAP2 (0.34) | METAP2METAP1ENPP1GRIN2B | |
| SCHEMBL6485 | 0.79 | METAP2 (0.42) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL4955472 | 0.79 | METAP2 (0.42) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL30884953 | 0.79 | METAP2 (0.42) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL29208955 | 0.79 | METAP2 (0.42) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL9569994 | 0.79 | METAP2 (0.42) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL1193887 | 0.78 | METAP2 (0.44) | METAP2METAP1ENPP1NPY5RLMNA | |
| SCHEMBL3691689 | 0.78 | PI4KA (0.55) | METAP2METAP1NOS2NOS1NOS3 | |
| SCHEMBL7073073 | 0.76 | RAD52 (0.42) | METAP2METAP1ENPP1NPY5RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 523 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849905-A | Biologically active phosphotriester-type nucleosides and methods for preparing same | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-12-15 | — | — | US | claimed |
| US-5770725-A | USES NOVEL GROUP, CHARACTERIZED BY THE PRESENCE OF-S-S-AND/OR S-C=Z (Z=O OR S) ENZYME LABILE BONDS WHICH LEADS, AFTER ENZYMATIC ACTIVATION, TO THE FORMATION OF UNSTABLE INTERMEDIATE WHICH RELEASES MONOPHOSPHATE OR MONOPHOSPHONATE | CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1998-06-23 | — | — | US | claimed |
| EP-0642528-B1 | PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS | CENTRE NAT RECH SCIENT (FR) | 1997-01-15 | — | — | EP | claimed |
| EP-0642528-A1 | PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS. | CENTRE NAT RECH SCIENT (FR) | 1995-03-15 | — | — | EP | claimed |
| WO-1993024510-A1 | PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1993-12-09 | — | — | WO | claimed |
| US-20220056441-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS INC (US) | 2022-02-24 | — | — | US | disclosed |
| EP-3926046-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | Sirna Therapeutics, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| EP-3354656-B1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS INC (US) | 2021-04-07 | — | — | EP | disclosed |
| US-10889815-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2021-01-12 | — | — | US | disclosed |
| US-10662428-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190233821-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) | BANK OF AMERICA, N.A. | 2019-08-01 | — | — | US | disclosed |
| US-10351852-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-20020037873-A1 | Biologically active phosphotriester-type compounds | CENTRE NATIONAL DE LA RECHERCH SIENTIFIQUE | 2002-03-28 | — | — | US | disclosed |
| US-6020482-A | Phosphotriester type biologically active compounds | CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2000-02-01 | — | — | US | disclosed |
| US-5849905-A | Biologically active phosphotriester-type nucleosides and methods for preparing same | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5770725-A | USES NOVEL GROUP, CHARACTERIZED BY THE PRESENCE OF-S-S-AND/OR S-C=Z (Z=O OR S) ENZYME LABILE BONDS WHICH LEADS, AFTER ENZYMATIC ACTIVATION, TO THE FORMATION OF UNSTABLE INTERMEDIATE WHICH RELEASES MONOPHOSPHATE OR MONOPHOSPHONATE | CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1998-06-23 | — | — | US | disclosed |
| WO-1998011121-A1 | BIOLOGICALLY ACTIVE PHOSPHOTRIESTER-TYPE COMPOUNDS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1998-03-19 | — | — | WO | disclosed |
| EP-0642528-B1 | PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS | CENTRE NAT RECH SCIENT (FR) | 1997-01-15 | — | — | EP | disclosed |
| EP-0642528-A1 | PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS. | CENTRE NAT RECH SCIENT (FR) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024510-A1 | PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1993-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662428-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | AGO2, SNRPE, SRRT | CACNA1H 3019/4885METAP2 2389/4885METAP1 1994/4885 |
| US-10889815-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | AGO2, SNRPE, SRRT | CACNA1H 3019/4885METAP2 2389/4885METAP1 1994/4885 |
| US-20220056441-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA) | AGO2, SNRPE, SRRT | CACNA1H 3019/4885METAP2 2389/4885METAP1 1994/4885 |
| US-20190233821-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) | AGO2, SNRPE, SRRT | CACNA1H 3019/4885METAP2 2389/4885METAP1 1994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.