SCHEMBL2354474

SCHEMBL2354474

Cc1cc(C)c(NCCO)c(C)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 5/20 0.48
GAA P10253 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
MAPK1 P28482 1/20 0.44
KDM4E B2RXH2 4/20 0.42
ALDH1A1 P00352 3/20 0.42
HSD17B10 Q99714 1/20 0.42
LMNA P02545 2/20 0.41
APP P05067 1/20 0.41
BCHE P06276 1/20 0.41
ACHE P22303 1/20 0.41
TSHR P16473 2/20 0.39
MAPT P10636 1/20 0.39
MITF O75030 1/20 0.37
TTR P02766 1/20 0.37
GLA P06280 1/20 0.37
POLB P06746 1/20 0.37
RAD52 P43351 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2756366 0.85 RAPGEF4 (0.57) RAPGEF4GAAALDH1A1LMNAMAPT
SCHEMBL5845349 0.81 RAPGEF4 (0.52) RAPGEF4GAAALDH1A1LMNAMAPT
SCHEMBL12963494 0.79 RAPGEF4 (0.50) RAPGEF4ALDH1A1LMNATSHRMAPT
SCHEMBL812880 0.79 RAPGEF4 (0.50) RAPGEF4GAAALDH1A1LMNAMAPT
SCHEMBL2335362 0.79 RAPGEF4 (0.50) RAPGEF4KMT2AALDH1A1LMNAACHE
SCHEMBL1004807 0.77 ALDH1A1 (0.46) GAAMEN1KMT2AMAPK1KDM4E
SCHEMBL813197 0.77 RAPGEF4 (0.48) RAPGEF4GAAALDH1A1LMNAMAPT
SCHEMBL13917945 0.77 RAPGEF4 (0.48) RAPGEF4ALDH1A1LMNA
SCHEMBL2354471 0.77 RAPGEF4 (0.48) RAPGEF4ALDH1A1LMNATSHRMAPT
SCHEMBL814620 0.77 RAPGEF4 (0.48) RAPGEF4GAAALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105085733-B A kind of catalyst component for olefin polymerization preparation method and corresponding catalyst 中国石油化工股份有限公司 2017-10-03 CN disclosed
CN-105085727-B A kind of catalytic component and its catalyst for olefinic polymerization 中国石油化工股份有限公司 2017-09-29 CN disclosed
CN-105085731-B A kind of catalyst component for olefin polymerization preparation method and corresponding catalyst 中国石油化工股份有限公司 2017-09-29 CN disclosed
US-7999039-B2 Catalytic polymerization of olefinic monomers in the presence of a high molecular weight catalyst and a low molecular weight catalyst in a polymerization reactor system; high melt strength DOW GLOBAL TECHNOLOGIES LLC (US) 2011-08-16 US disclosed
US-4788277-A OXIDATIVE COUPLING, CATALYST CONTAINING COPPER, DIAMINE, HALOGEN ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1988-11-29 US disclosed