Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9497710 | 0.83 | KDM4E (0.30) | KDM4ECYP2C9CYP2C19 | |
| SCHEMBL23613007 | 0.83 | ALDH1A1 (0.43) | CNR2CYP2C9CYP2C19ALDH1A1HPGD | |
| SCHEMBL13887653 | 0.82 | ASAH1 (0.38) | CNR2ALDH1A1NPSR1ASAH1L3MBTL1 | |
| SCHEMBL14707759 | 0.82 | ASAH1 (0.38) | CNR2ALDH1A1NPSR1ASAH1L3MBTL1 | |
| SCHEMBL14707758 | 0.82 | ASAH1 (0.38) | CNR2ALDH1A1NPSR1ASAH1L3MBTL1 | |
| SCHEMBL26504336 | 0.79 | TAS1R3 (0.46) | CYP2C9CYP2C19ASAH1MAPK1 | |
| SCHEMBL25867489 | 0.79 | ACACB (0.34) | CNR2KDM4ECYP2C9CYP2C19GAA | |
| SCHEMBL25867490 | 0.78 | CYP2C9 (0.39) | CNR2KDM4ECYP2C9CYP2C19GAA | |
| SCHEMBL19699581 | 0.77 | MMP1 (0.48) | CNR2KDM4EGAAALDH1A1NPSR1 | |
| SCHEMBL19699582 | 0.77 | MMP1 (0.48) | CNR2KDM4EGAAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188775-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | GENENTECH, INC. (US) | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188775-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | TEAD2, TEAD1, SULT2A1 | CNR2 23/4885KDM4E 848/4885CYP2C9 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.