Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | TK1 | P04183 | 1/20 | 0.50 |
| ▸ | TK2 | O00142 | 5/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354060 | 0.92 | ADRA1D (0.60) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL2353857 | 0.91 | ADRA1B (0.68) | ADRA1AADRA1BADRA1DLMNADRD2 | |
| SCHEMBL2346272 | 0.88 | ADRA1D (0.67) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL2350687 | 0.88 | ADRA1A (0.56) | ADRA1AADRA1BADRA1DLMNADRD2 | |
| SCHEMBL2350823 | 0.87 | ADRA1D (0.72) | ADRA1AADRA1BADRA1DKDM4EDRD2 | |
| SCHEMBL2350383 | 0.86 | ADRA1A (0.63) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL2350672 | 0.86 | ADRA1A (0.62) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL593078 | 0.85 | MAPK1 (0.54) | ADRA1AADRA1BADRA1DKDM4ELMNA | |
| SCHEMBL2351486 | 0.85 | ADRA1B (0.75) | ADRA1AADRA1BADRA1DDRD2HTR7 | |
| SCHEMBL7833683 | 0.84 | ADRA1D (0.75) | ADRA1AADRA1BADRA1DKDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008488-B2 | Pyrimidin-2-one compounds and their use as dopamine D3 receptor ligands | ABBOTT GMBH & CO. KG (DE) | 2011-08-30 | — | — | US | disclosed |
| EP-1601659-B1 | PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | ABBOTT GMBH & CO KG (DE) | 2008-01-16 | — | — | EP | disclosed |
| US-20060235004-A1 | Pyrimidin-2-one compounds and their use as dopamine d3 receptor ligands | ABBOT GMBH & CO. KG (DE) | 2006-10-19 | — | — | US | disclosed |
| EP-1601659-A1 | PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | Abbott GmbH & Co. KG (DE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004080981-A1 | PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | ABBOTT GMBH & CO. KG (DE) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235004-A1 | Pyrimidin-2-one compounds and their use as dopamine d3 receptor ligands | ADRB3, DRD3, OPRL1 | ADRA1A 101/4885ADRA1B 78/4885ADRA1D 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.