Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.75 |
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | DRD3 | P35462 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 7/20 | 0.61 |
| ▸ | HTR1A | P08908 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7834507 | 0.99 | ADRA1D (0.74) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2350823 | 0.98 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2351486 | 0.87 | ADRA1B (0.75) | ADRA1DADRA1AADRA1BDRD2HTR7 | |
| Hydrochloric Acid SCHEMBL7833133 | 0.87 | ADRA1A (0.64) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2353857 | 0.86 | ADRA1B (0.68) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7831192 | 0.85 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9045935 | 0.85 | ADRA1A (0.98) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2354965 | 0.84 | ADRA1A (0.66) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2349477 | 0.84 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2351537 | 0.84 | ADRA1B (0.55) | ADRA1DADRA1AADRA1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |