Water

Water

SCHEMBL2355003

C=CC(=O)NCCC[N+](C)(C)C.[OH-]

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ZDHHC20 Q5W0Z9 1/20 0.56
ZDHHC2 Q9UIJ5 1/20 0.56
KMT2A Q03164 1/20 0.46
ATM Q13315 1/20 0.46
TSHR P16473 2/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPK1 P28482 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
GAA P10253 1/20 0.41
TGM2 P21980 4/20 0.38
ACHE P22303 2/20 0.38
CBLB Q13191 5/20 0.37
APOBEC3A P31941 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
MAPT P10636 1/20 0.35
BBOX1 O75936 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL192702 0.98 ZDHHC20 (0.58) ZDHHC20ZDHHC2KMT2AATMTSHR
Bromide SCHEMBL475865 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Hydrochloric Acid SCHEMBL26669425 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Iodide SCHEMBL2254575 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Iodide SCHEMBL17105877 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Fluoride Ion SCHEMBL17105892 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Hydrochloric Acid SCHEMBL127417 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Hydrochloric Acid SCHEMBL3405400 0.96 ZDHHC20 (0.56) ZDHHC20ZDHHC2KMT2AATMTSHR
Hydrochloric Acid SCHEMBL31470991 0.94 ZDHHC20 (0.55) ZDHHC20ZDHHC2KMT2AATMTSHR
Chloromethane SCHEMBL27393558 0.94 ZDHHC20 (0.55) ZDHHC20ZDHHC2KMT2AATMTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180185289-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION PALADIN LABS INC (CA) 2018-07-05 US claimed
US-20160310432-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION PALADIN LABS INC (CA) 2016-10-27 US claimed
EP-2367541-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION Labopharm Inc. (CA) 2011-09-28 EP claimed
US-20100239662-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION ENDO OPERATIONS LIMITED (IE) 2010-09-23 US claimed
WO-2010069050-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION LABOPHARM INC. (CA) 2010-06-24 WO claimed
US-20090175937-A1 Misuse Preventative, Controlled Release Formulation LABOPHARM, INC. 2009-07-09 US claimed
JP-2007503991-A 2007-03-01 JP claimed
US-7179851-B2 Damage-resistant superabsorbent materials KIMBERLY-CLARK WORLDWIDE, INC. (US) 2007-02-20 US claimed
WO-2005025628-A1 DAMAGE-RESISTANT SUPERABSORBENT MATERIALS KIMBERLY-CLARK WORLDWIDE, INC. (US) 2005-03-24 WO claimed
US-20050054784-A1 Withstand mechanical forces without reduction in absorbency properties; diapers; Absorbent Product Processing Simulation Test; treated by adding a coating of a hydrophilic soft polymer crosslinked with a (meth)acrylate having alkoxysilane groups the superabsorbent material KIMBERLY-CLARK WORLDWIDE, INC. 2005-03-10 US claimed
US-20200030752-A1 MEMBRANES FOR GAS SEPARATION OHIO STATE INNOVATION FOUNDATION 2020-01-30 US disclosed
EP-3344372-A1 MEMBRANES FOR GAS SEPARATION Ohio State Innovation Foundation (US) 2018-07-11 EP disclosed
US-20180185292-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION PALADIN LABS INC (CA) 2018-07-05 US disclosed
US-20180185289-A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION PALADIN LABS INC (CA) 2018-07-05 US disclosed
US-20170056839-A1 MEMBRANES FOR GAS SEPARATION OHIO STATE INNOVATION FOUNDATION 2017-03-02 US disclosed
WO-2005067854-A1 STRETCHABLE ABSORBENT COMPOSITES HAVING HIGH PERMEABILITY KIMBERLY-CLARK WORLDWIDE, INC. (US) 2005-07-28 WO disclosed
US-20050148964-A1 Absorbent structure having profiled stabilization KIMBERLY-CLARK WORLDWIDE, INC. 2005-07-07 US disclosed
US-20050137085-A1 Stretchable absorbent composites having high permeability KIMBERLY-CLARK WORLDWIDE, INC. 2005-06-23 US disclosed
WO-2005025628-A1 DAMAGE-RESISTANT SUPERABSORBENT MATERIALS KIMBERLY-CLARK WORLDWIDE, INC. (US) 2005-03-24 WO disclosed
US-20050054784-A1 Withstand mechanical forces without reduction in absorbency properties; diapers; Absorbent Product Processing Simulation Test; treated by adding a coating of a hydrophilic soft polymer crosslinked with a (meth)acrylate having alkoxysilane groups the superabsorbent material KIMBERLY-CLARK WORLDWIDE, INC. 2005-03-10 US disclosed