Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 4/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.47 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181137 | 0.83 | DGAT1 (0.52) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2181145 | 0.83 | DGAT1 (0.52) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2180786 | 0.82 | DGAT1 (0.49) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2355332 | 0.82 | DGAT1 (0.49) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2181269 | 0.81 | RAB9A (0.43) | DGAT1CSGALNACT1THRBCA12CA1 | |
| SCHEMBL2355335 | 0.81 | DGAT1 (0.48) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2176533 | 0.78 | PIK3CA (0.37) | DGAT1CSGALNACT1CNR1THRBPIK3CA | |
| SCHEMBL2179929 | 0.77 | SDCBP (0.46) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2177867 | 0.77 | SDCBP (0.46) | P2RY1DGAT1CSGALNACT1IDO1GRIK1 | |
| SCHEMBL2178378 | 0.76 | KDR (0.51) | DGAT1CSGALNACT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |