Sugi Predict

Sugi Predict / Compounds / SCHEMBL2176533

SCHEMBL2176533

SCHEMBL2176533

CC(C)[C@@](C)(C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)cc2C1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CA P42336 1/20 0.37
▸ MTOR P42345 1/20 0.37
▸ CSGALNACT1 Q8TDX6 1/20 0.37
▸ DGAT1 O75907 6/20 0.37
▸ KDR P35968 5/20 0.37
▸ THRB P10828 1/20 0.35
▸ KIT P10721 1/20 0.34
▸ MAP3K5 Q99683 2/20 0.34
▸ AURKA O14965 1/20 0.34
▸ DYRK3 O43781 1/20 0.34
▸ ROCK2 O75116 1/20 0.34
▸ RPS6KA5 O75582 1/20 0.34
▸ PRKD3 O94806 1/20 0.34
▸ MAP4K4 O95819 1/20 0.34
▸ CHEK2 O96017 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ NTRK1 P04629 1/20 0.34
▸ INSR P06213 1/20 0.34
▸ LCK P06239 1/20 0.34
▸ FYN P06241 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2181269 0.87 RAB9A (0.43) PIK3CAMTORCSGALNACT1DGAT1KDR
SCHEMBL2178378 0.85 KDR (0.51) CSGALNACT1DGAT1KDRKITAURKA
SCHEMBL2178898 0.79 LMNA (0.43) CSGALNACT1DGAT1KDRTHRB
SCHEMBL2178892 0.79 LMNA (0.43) CSGALNACT1DGAT1KDRTHRB
SCHEMBL2355341 0.78 P2RY1 (0.49) PIK3CAMTORCSGALNACT1DGAT1THRB
SCHEMBL13719201 0.76 KDM4E (0.43) NPC1RAB9AMEN1MAPTHTT
SCHEMBL2176527 0.76 GAA (0.45) CSGALNACT1DGAT1KDRTHRBMAPK1
SCHEMBL2176529 0.76 LMNA (0.46) CSGALNACT1KDRTHRBAURKADYRK3
SCHEMBL2176524 0.76 LMNA (0.46) CSGALNACT1KDRTHRBAURKADYRK3
SCHEMBL2178323 0.74 KDR (0.55) DGAT1KDRKITAURKAROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US claimed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US claimed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP claimed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO claimed
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US disclosed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US disclosed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE DGAT1, DGAT2, LCAT PIK3CA 1050/4885MTOR 1314/4885CSGALNACT1 783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.