Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059752 | 0.74 | ATM (0.44) | NAMPTTPSAB1TPSD1TPSG1KDM1A | |
| SCHEMBL13694472 | 0.73 | NAMPT (0.47) | NAMPTTPSAB1TPSD1TPSG1KDM1A | |
| SCHEMBL22874790 | 0.72 | NAMPT (0.54) | NAMPTTPSAB1TPSD1TPSG1CYP1A2 | |
| SCHEMBL25303116 | 0.71 | DPP4 (0.38) | NAMPTTPSAB1TPSD1TPSG1KDM1A | |
| SCHEMBL12197568 | 0.69 | NAMPT (0.47) | NAMPTTPSAB1TPSD1TPSG1CYP1A2 | |
| SCHEMBL22875133 | 0.66 | TPSAB1 (0.48) | NAMPTTPSAB1TPSD1TPSG1 | |
| SCHEMBL902894 | 0.66 | CYP19A1 (0.44) | CYP19A1 | |
| SCHEMBL21872569 | 0.65 | CHRNB2 (0.50) | NAMPTCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL25307104 | 0.64 | KDM1A (0.45) | NAMPTTPSAB1TPSD1TPSG1KDM1A | |
| SCHEMBL15712634 | 0.64 | CYP19A1 (0.49) | CYP19A1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127586-A1 | PROTEIN TYROSINE PHOSPHATASE DEGRADERS AND METHODS OF USE THEREOF | CALICO LIFE SCIENCES LLC (US) | 2021-06-24 | — | — | WO | disclosed |