Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9315866 | 0.98 | GRIN2B (0.59) | GRIN2BOPRM1OPRD1OPRK1L3MBTL1 | |
| SCHEMBL2354359 | 0.90 | GRIN2B (0.62) | GRIN2BOPRM1OPRD1OPRK1L3MBTL1 | |
| SCHEMBL4692444 | 0.84 | OPRM1 (0.51) | GRIN2BOPRM1OPRD1OPRK1L3MBTL1 | |
| SCHEMBL27544724 | 0.84 | GRIN2B (0.58) | GRIN2BOPRM1OPRD1OPRK1MEN1 | |
| SCHEMBL10700575 | 0.83 | OPRM1 (0.61) | GRIN2BOPRM1OPRD1OPRK1L3MBTL1 | |
| SCHEMBL9455273 | 0.83 | GRIN2B (0.58) | GRIN2BL3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL11440086 | 0.81 | KCNH2 (0.50) | GRIN2BOPRM1OPRD1OPRK1L3MBTL1 | |
| SCHEMBL10697937 | 0.81 | OPRM1 (0.63) | GRIN2BOPRM1OPRD1OPRK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL9454768 | 0.81 | GRIN2B (0.57) | GRIN2BL3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL3375958 | 0.81 | GRIN2B (0.60) | GRIN2BL3MBTL1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256698-A | Binding neurotransmitters | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-10-26 | — | — | US | claimed |
| EP-0540576-A1 | PSYCHOACTIVE DRUG AND TREATMENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-05-12 | — | — | EP | claimed |
| WO-1992001449-A1 | PSYCHOACTIVE DRUG AND TREATMENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-02-06 | — | — | WO | claimed |
| US-20110257225-A1 | CYCLOHEXYLAMINE DERIVATIVE CONTAINING PHENYL GROUP, AND THERAPEUTIC AGENT FOR DISEASES ACCOMPANIED BY CENTRAL NERVOUS SYSTEM DISORDERS | M'S SCIENCE CORPORATION (JP) | 2011-10-20 | — | — | US | disclosed |
| CN-102197017-A | Phenyl-containing cyclohexylamine derivatives and remedies for central nervous system disorder-associated diseases | MS SCIENCE CORP | 2011-09-21 | — | — | CN | disclosed |
| EP-2357165-A1 | CYCLOHEXYLAMINE DERIVATIVE CONTAINING PHENYL GROUP, AND THERAPEUTIC AGENT FOR DISEASES ACCOMPANIED BY CENTRAL NERVOUS SYSTEM DISORDERS | M's Science Corporation (JP) | 2011-08-17 | — | — | EP | disclosed |
| WO-1994016685-A1 | OPHTHALMIC USES OF SIGNA AGONISTS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1994-08-04 | — | — | WO | disclosed |
| US-5256698-A | Binding neurotransmitters | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-10-26 | — | — | US | disclosed |
| US-5256698-A | Binding neurotransmitters | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0540576-A1 | PSYCHOACTIVE DRUG AND TREATMENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-05-12 | — | — | EP | disclosed |
| EP-0540576-A1 | PSYCHOACTIVE DRUG AND TREATMENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001449-A1 | PSYCHOACTIVE DRUG AND TREATMENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-02-06 | — | — | WO | disclosed |
| WO-1992001449-A1 | PSYCHOACTIVE DRUG AND TREATMENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257225-A1 | CYCLOHEXYLAMINE DERIVATIVE CONTAINING PHENYL GROUP, AND THERAPEUTIC AGENT FOR DISEASES ACCOMPANIED BY CENTRAL NERVOUS SYSTEM DISORDERS | SIGMAR1, OPRM1, OPRK1 | GRIN2B 41/4885OPRM1 2/4885OPRD1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.