SCHEMBL23563231

SCHEMBL23563231

C[C@H](CCCC(C)(C)O)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OSBP P22059 6/20 1.00
NR1H3 Q13133 6/20 1.00
RORC P51449 5/20 1.00
OSBP2 Q969R2 3/20 1.00
CRYAB P02511 1/20 1.00
HMGCR P04035 1/20 1.00
ITGB3 P05106 1/20 1.00
ITGAV P06756 1/20 1.00
SREBF2 Q12772 1/20 1.00
NPC1L1 Q9UHC9 1/20 1.00
GRIN1 Q05586 6/20 0.91
GRIN2A Q12879 6/20 0.91
GRIN2B Q13224 5/20 0.91
USP2 O75604 1/20 0.80
LMNA P02545 1/20 0.80
ABCB1 P08183 1/20 0.80
CYP46A1 Q9Y6A2 1/20 0.80
PTPN1 P18031 2/20 0.74
DHCR24 Q15392 1/20 0.73
EPHA2 P29317 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6388323 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL15435130 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL3420850 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL177268 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL25035613 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL177267 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL17049791 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL14420777 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL22559541 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB
SCHEMBL20299556 1.00 OSBP (1.00) OSBPNR1H3RORCOSBP2CRYAB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4637722-A1 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE, FORMULATIONS THEREOF AND METHODS FOR PREPARING, AND MEDICAL USES OF SAME Durect Corporation (US) 2025-10-29 EP disclosed
EP-4638463-A1 SALTS INCLUDING CRYSTALLINE SALTS OF 25-HYDROXY-CHOLEST-5-EN-3-SULFATE AND METHODS FOR PREPARING SAME Durect Corporation (US) 2025-10-29 EP disclosed
WO-2024138203-A1 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE, FORMULATIONS THEREOF AND METHODS FOR PREPARING, AND MEDICAL USES OF SAME DURECT CORPORATION (US) 2024-06-27 WO disclosed
WO-2024138203-A1 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE, FORMULATIONS THEREOF AND METHODS FOR PREPARING, AND MEDICAL USES OF SAME DURECT CORPORATION (US) 2024-06-27 WO disclosed
EP-4359420-A1 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE AND METHODS FOR PREPARING, AND USES OF, SAME Durect Corporation (US) 2024-05-01 EP disclosed
US-20230181744-A1 COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES FUDAN UNIVERSITY (CN) 2023-06-15 US disclosed
US-20230181744-A1 COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES FUDAN UNIVERSITY (CN) 2023-06-15 US disclosed
US-20230056273-A1 CRYSTALLINE AND LIQUID CRYSTALLINE 25-HYDROXY-CHOLEST-5-EN-3-SULFATE SODIUM AND METHODS FOR PREPARING SAME JPMORGAN CHASE BANK, N.A. 2023-02-23 US disclosed
WO-2022272103-A1 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE AND METHODS FOR PREPARING, AND USES OF, SAME DURECT CORPORATION (US) 2022-12-29 WO disclosed
EP-4081028-A1 CRYSTALLINE AND LIQUID CRYSTALLINE 25-HYDROXY-CHOLEST-5-EN-3-SULFATE SODIUM AND METHODS FOR PREPARING SAME Durect Corporation (US) 2022-11-02 EP disclosed
CN-115103591-A Crystalline and liquid crystalline 25-hydroxy-cholest-5-en-3-sodium sulfate and process for preparing same 度勒科特公司 2022-09-23 CN disclosed
WO-2021213518-A1 COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES 复旦大学 (CN) 2021-10-28 WO disclosed
WO-2021133976-A1 CRYSTALLINE AND LIQUID CRYSTALLINE 25-HYDROXY-CHOLEST-5-EN-3-SULFATE SODIUM AND METHODS FOR PREPARING SAME DURECT CORPORATION (US) 2021-07-01 WO disclosed
WO-2021120127-A1 METHOD FOR PREPARING CHOLESTEROL, DERIVATIVE AND ANALOGUE THEREOF 湖南科瑞生物制药股份有限公司 2021-06-24 WO disclosed
WO-2021121239-A1 METHOD FOR PREPARING CHOLESTEROL, DERIVATIVE THEREOF, AND ANALOG THEREOF 湖南科瑞生物制药股份有限公司 2021-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230181744-A1 COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES MAP1LC3B, MAP1LC3A, SQSTM1 OSBP 148/4885NR1H3 42/4885RORC 483/4885
US-20230056273-A1 CRYSTALLINE AND LIQUID CRYSTALLINE 25-HYDROXY-CHOLEST-5-EN-3-SULFATE SODIUM AND METHODS FOR PREPARING SAME CYP27A1, CYP46A1, PCSK9 OSBP 329/4885NR1H3 5/4885RORC 372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.