Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ELANE | P08246 | 1/20 | 0.61 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | PLK1 | P53350 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466712 | 0.87 | MEN1 (0.72) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2025586 | 0.87 | MEN1 (0.72) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2291746 | 0.86 | MEN1 (0.67) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2292518 | 0.86 | SERPINE1 (0.71) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2289650 | 0.83 | F10 (0.70) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8027764 | 0.83 | MEN1 (0.67) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11594005 | 0.82 | KDM4E (0.58) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9575455 | 0.82 | KDM4E (0.80) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL31730773 | 0.82 | KDM4E (0.80) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2291001 | 0.81 | NR1H4 (0.62) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989657-B2 | Anthranilic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | claimed |
| US-20090247637-A1 | Novel Anthranilic Acid Derivatives | DEHMLOW HENRIETTA | 2009-10-01 | — | — | US | claimed |
| JP-2008546661-A | — | — | 2008-12-25 | — | — | JP | claimed |
| EP-1896396-A1 | ANTHRANILIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-03-12 | — | — | EP | claimed |
| WO-2006134040-A1 | ANTHRANILIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-21 | — | — | WO | claimed |
| US-20060281810-A1 | Novel anthranilic acid derivatives | HOFFMANN-LA ROCHE INC. | 2006-12-14 | — | — | US | claimed |
| US-7989657-B2 | Anthranilic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090247637-A1 | Novel Anthranilic Acid Derivatives | DEHMLOW HENRIETTA | 2009-10-01 | — | — | US | disclosed |
| EP-1896396-A1 | ANTHRANILIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006134040-A1 | ANTHRANILIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-21 | — | — | WO | disclosed |
| US-20060281810-A1 | Novel anthranilic acid derivatives | HOFFMANN-LA ROCHE INC. | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281810-A1 | Novel anthranilic acid derivatives | GPR84, HCAR1, GPR88 | SMN1; SMN2 3830/4885RAB9A 1353/4885NPC1 3594/4885 |
| US-20090247637-A1 | Novel Anthranilic Acid Derivatives | GPR84, GPR88, HCAR1 | SMN1; SMN2 3904/4885RAB9A 1445/4885NPC1 3210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.