Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | LYN | P07948 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358573 | 0.81 | TRPA1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL2357216 | 0.76 | HCRTR1 (0.40) | HCRTR1HCRTR2BRAFABL1DDR1 | |
| SCHEMBL2355869 | 0.76 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL2358231 | 0.75 | CHRM1 (0.47) | CSF1RHCRTR1HCRTR2FLT3 | |
| SCHEMBL2358322 | 0.75 | SORT1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL2356052 | 0.75 | KDM4E (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL1927027 | 0.73 | CSF1R (0.55) | CSF1RLYNKITMAP3K7MAP4K2 | |
| SCHEMBL2359300 | 0.72 | BRAF (0.45) | HCRTR1HCRTR2BRAF | |
| SCHEMBL2357713 | 0.72 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL2356255 | 0.72 | MALT1 (0.46) | CSF1RKITFLT3LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350052-A2 | ANTIPROLIFERATIVE COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010034838-A2 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | claimed |