Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 6/20 | 0.33 |
| ▸ | FNTB | P49356 | 6/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23580045 | 0.85 | NQO2 (0.33) | BUB1DCTPP1 | |
| SCHEMBL23579780 | 0.84 | BUB1 (0.35) | BUB1METMAPT | |
| SCHEMBL23580792 | 0.70 | MAPT (0.44) | CYP19A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL23579898 | 0.68 | DCTPP1 (0.60) | MEN1KMT2ARAB9ADCTPP1CFTR | |
| SCHEMBL4511606 | 0.66 | HTR7 (0.51) | CYP19A1POLBMAPT | |
| SCHEMBL23580790 | 0.66 | CFTR (0.48) | DCTPP1CFTRLMNACASP6MAPT | |
| SCHEMBL23579734 | 0.66 | AR (0.47) | DCTPP1CFTRLMNA | |
| SCHEMBL23579863 | 0.64 | DPP4 (0.45) | CYP19A1MEN1KMT2AFNTAFNTB | |
| SCHEMBL23579932 | 0.64 | MEN1 (0.42) | MEN1KMT2ARAB9ANPC1PAX8 | |
| SCHEMBL16931512 | 0.63 | GLS (0.61) | CYP19A1MEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339150-B2 | Benzimidazole compounds as HDAC6 inhibitors | ONKURE, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20220041584-A1 | BENZIMIDAZOLE COMPOUNDS AS HDAC6 INHIBITORS | ONKURE, INC. (US) | 2022-02-10 | — | — | US | disclosed |
| WO-2021133957-A1 | BENZIMIDAZOLE COMPOUNDS AS HDAC6 INHIBITORS | ONKURE, INC. (US) | 2021-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041584-A1 | BENZIMIDAZOLE COMPOUNDS AS HDAC6 INHIBITORS | HDAC6, HDAC1, HDAC11 | BUB1 1360/4885CYP19A1 1916/4885MEN1 3567/4885 |
| US-11339150-B2 | Benzimidazole compounds as HDAC6 inhibitors | HDAC6, HDAC1, HDAC11 | BUB1 1360/4885CYP19A1 1916/4885MEN1 3567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.