Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 7/20 | 0.35 |
| ▸ | ACACA | Q13085 | 7/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584451 | 0.90 | JAK2 (0.40) | JAK2JAK1CCRL2DRD2CKS1B | |
| SCHEMBL23584567 | 0.85 | DRD2 (0.38) | JAK2JAK1CCRL2DRD2CKS1B | |
| SCHEMBL23584729 | 0.85 | PRMT5 (0.38) | JAK2JAK1CCRL2DRD2PRMT5 | |
| SCHEMBL22434971 | 0.82 | SIRT2 (0.41) | JAK2JAK1PRMT5WDR77 | |
| SCHEMBL23584552 | 0.79 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL23584625 | 0.79 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL23584710 | 0.77 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584551 | 0.76 | DDR1 (0.36) | CCRL2DRD2CKS1BSKP1SKP2 | |
| SCHEMBL22435004 | 0.75 | PRMT5 (0.37) | JAK2JAK1PRMT5WDR77 | |
| SCHEMBL23584612 | 0.74 | MAP4K4 (0.47) | JAK2JAK1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |