Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | TXK | P42681 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23587679 | 0.91 | BTK (0.58) | BTKCDK7CDK9JAK2JAK3 | |
| SCHEMBL9277964 | 0.76 | BTK (0.59) | BTKCDK7JAK2JAK3LYN | |
| SCHEMBL14634664 | 0.74 | BTK (0.57) | BTKCDK7JAK2JAK3LYN | |
| SCHEMBL23587690 | 0.74 | KDR (0.62) | BTKCDK7JAK2JAK3LYN | |
| SCHEMBL12575010 | 0.74 | BTK (1.00) | BTKCDK7JAK2JAK3LYN | |
| SCHEMBL14024764 | 0.74 | CDC7 (0.49) | SYKPAK4PAK1KDRIGF1R | |
| SCHEMBL4978576 | 0.72 | BTK (0.47) | BTKCDK7JAK2JAK3LYN | |
| SCHEMBL29808697 | 0.71 | PAK4 (0.41) | CDK7CDK9SYKPAK4PAK1 | |
| SCHEMBL21163561 | 0.71 | PAK4 (0.41) | CDK7CDK9SYKPAK4PAK1 | |
| SCHEMBL2437220 | 0.69 | BTK (0.54) | BTKCDK7JAK2JAK3LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133742-A1 | STABILIZATION OF MHC COMPLEXES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-01 | — | — | WO | disclosed |