Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26075529 | 0.85 | ESR1 (0.53) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26074059 | 0.85 | LMNA (0.47) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26649544 | 0.85 | PLA2G2A (0.65) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL26074084 | 0.84 | DHODH (0.66) | ALDH1A1PLA2G2ADHODHGAAERN1 | |
| SCHEMBL26075554 | 0.83 | DHODH (0.51) | ALDH1A1PLA2G2ADHODHGAAMEN1 | |
| SCHEMBL29617652 | 0.82 | DHODH (0.71) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23576327 | 0.82 | DHODH (0.71) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26075343 | 0.81 | PLA2G2A (0.39) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26075573 | 0.81 | DHODH (0.45) | ALDH1A1HPGDPLA2G2ADHODHGAA | |
| SCHEMBL26075352 | 0.81 | DHODH (0.45) | PLA2G2ADHODHERN1TP53PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021134045-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2021-07-01 | — | — | WO | disclosed |