Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TGM6 | O95932 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23591772 | 0.90 | EPHX2 (0.54) | EPHX2NPC1MAPK1MAP3K7FGFR1 | |
| SCHEMBL22453625 | 0.78 | EPHX2 (0.45) | EPHX2NPC1LMNAMAPTHIF1A | |
| SCHEMBL25782484 | 0.76 | MAPK1 (0.38) | EPHX2NPC1MAPK1MAP3K7FGFR1 | |
| SCHEMBL22452479 | 0.73 | EPHX2 (0.50) | EPHX2NPC1LMNAMAPTHIF1A | |
| SCHEMBL11306215 | 0.71 | TGM2 (0.65) | NPC1MAPK1MAP3K7FGFR1SRC | |
| SCHEMBL1961608 | 0.71 | TGM2 (0.67) | SRCLMNAMAPTMAPK3EGFR | |
| SCHEMBL22452506 | 0.69 | EPHX2 (0.46) | EPHX2NPC1MAPTHIF1AEPAS1 | |
| SCHEMBL11306206 | 0.68 | TGM2 (0.68) | NPC1MAPK1FGFR1MAPTMAPK3 | |
| SCHEMBL31555348 | 0.68 | HIF1A (0.60) | EPHX2NPC1LMNAMAPTHIF1A | |
| SCHEMBL22452498 | 0.68 | HIF1A (0.60) | EPHX2NPC1LMNAMAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133896-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-07-01 | — | — | WO | disclosed |