Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 18/20 | 0.36 |
| ▸ | PLG | P00747 | 12/20 | 0.36 |
| ▸ | PLAT | P00750 | 8/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31357614 | 1.00 | PLAU (0.36) | PLAUPLGPLATDGAT1BACE1 | |
| SCHEMBL31357691 | 1.00 | PLAU (0.36) | PLAUPLGPLATDGAT1BACE1 | |
| SCHEMBL31357705 | 0.89 | CTSL (0.35) | PLAUPLGPLATDGAT1 | |
| SCHEMBL28809392 | 0.89 | CTSL (0.35) | PLAUPLGPLATDGAT1 | |
| SCHEMBL31357656 | 0.88 | BACE1 (0.34) | DGAT1BACE1 | |
| SCHEMBL23595100 | 0.88 | BACE1 (0.34) | DGAT1BACE1 | |
| SCHEMBL31357637 | 0.88 | BACE1 (0.34) | DGAT1BACE1 | |
| SCHEMBL23582980 | 0.86 | PLAU (0.38) | PLAUPLGPLAT | |
| SCHEMBL23595020 | 0.84 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL31357586 | 0.84 | DGAT1 (0.32) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114846013-A | Novel aminoaryl derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-02 | — | — | CN | disclosed |
| WO-2021133035-A1 | NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF | 주식회사 엘지화학 | 2021-07-01 | — | — | WO | disclosed |