Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL8699361 | 0.87 | GID4 (0.45) | ALDH1A1IDO1BLM | |
| SCHEMBL8516651 | 0.77 | AURKA (0.46) | ALDH1A1HAO1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL1087686 | 0.75 | GID4 (0.43) | ALDH1A1IDO1BLM | |
| SCHEMBL5732694 | 0.75 | IDO1 (0.50) | HTTALDH1A1IDO1BLM | |
| SCHEMBL29934643 | 0.75 | IDO1 (0.50) | HTTALDH1A1IDO1BLM | |
| SCHEMBL30252198 | 0.75 | IDO1 (0.50) | HTTALDH1A1IDO1BLM | |
| SCHEMBL177082 | 0.75 | IDO1 (0.50) | HTTALDH1A1IDO1BLM | |
| SCHEMBL3812210 | 0.75 | IDO1 (0.50) | HTTALDH1A1IDO1BLM | |
| SCHEMBL20478857 | 0.75 | TAS1R3 (0.45) | ALDH1A1TAS1R3TAS1R1TAS1R2MAPK1 | |
| SCHEMBL15129434 | 0.75 | TAS1R3 (0.45) | ALDH1A1TAS1R3TAS1R1TAS1R2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352727-A1 | TRPV1 ANTAGONISTS | Abbott Laboratories (US) | 2011-08-10 | — | — | EP | claimed |
| WO-2010045402-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-04-22 | — | — | WO | claimed |