SCHEMBL2359770

SCHEMBL2359770

Clc1[c]cc2cc3c(cc2n1)OCO3

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.41
PDGFRA P16234 1/20 0.41
ALDH1A1 P00352 8/20 0.38
KDM4E B2RXH2 7/20 0.38
HPGD P15428 6/20 0.38
HSD17B10 Q99714 5/20 0.38
MAPT P10636 5/20 0.38
SMN1; SMN2 Q16637 4/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
TP53 P04637 3/20 0.38
TSHR P16473 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
PKM P14618 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP2C19 P33261 1/20 0.38
RPS6KB2 Q9UBS0 1/20 0.35
GAA P10253 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL527950 0.70 KDM4E (0.43) PDGFRBPDGFRAALDH1A1KDM4EHPGD
SCHEMBL5562603 0.68 SRC (0.42) PDGFRBPDGFRAALDH1A1KDM4EHPGD
SCHEMBL527216 0.67 ALDH1A1 (0.40) PDGFRBPDGFRAALDH1A1KDM4EHPGD
SCHEMBL7163627 0.66 EGFR (0.48) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL30250019 0.65 CYP3A4 (0.57) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL10638685 0.65 ALDH1A1 (0.57) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL10635467 0.65 CYP3A4 (0.57) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL717364 0.65 CYP3A4 (0.35) ALDH1A1HSD17B10SMN1; SMN2MEN1KMT2A
SCHEMBL30682087 0.64 KMT2A (0.46) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL3768019 0.63 EGFR (0.49) ALDH1A1KDM4EHPGDHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140370121-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2014-12-18 US claimed
US-8859532-B2 Materials and method for inhibiting replication protein A and uses thereof INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) 2014-10-14 US claimed
US-20130028989-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2013-01-31 US claimed
EP-2531032-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF Indiana University Research and Technology Corporation (US) 2012-12-12 EP claimed
WO-2011097545-A9 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORTION (US) 2011-11-17 WO claimed
WO-2011097545-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORTION (US) 2011-08-11 WO claimed
US-20100292266-A1 Oxazolyl Piperidine Modulators of Fatty Acid Amide Hydrolase JANSSEN PHARMACEUTICA NV (BE) 2010-11-18 US claimed
EP-2023728-A2 OXAZOLYL PIPERIDINE MODULATORS OF FATTY ACID AMIDE HYDROLASE Janssen Pharmaceutica, N.V. (BE) 2009-02-18 EP claimed
WO-2007140005-A2 OXAZOLYL PIPERIDINE MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-12-06 WO claimed
EP-2531032-B1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF UNIV INDIANA RES & TECH CORP (US) 2019-04-10 EP disclosed
US-9730942-B2 Materials and method for inhibiting replication protein A and uses thereof INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-08-15 US disclosed
US-20170182055-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF UNIV INDIANA RES & TECH CORP (US) 2017-06-29 US disclosed
US-9533969-B2 Materials and method for inhibiting replication protein A and uses thereof INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-01-03 US disclosed
US-20140370121-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2014-12-18 US disclosed
EP-2531032-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF Indiana University Research and Technology Corporation (US) 2012-12-12 EP disclosed
WO-2011097545-A9 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORTION (US) 2011-11-17 WO disclosed
WO-2011097545-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORTION (US) 2011-08-11 WO disclosed
US-20100292266-A1 Oxazolyl Piperidine Modulators of Fatty Acid Amide Hydrolase JANSSEN PHARMACEUTICA NV (BE) 2010-11-18 US disclosed
EP-2023728-A2 OXAZOLYL PIPERIDINE MODULATORS OF FATTY ACID AMIDE HYDROLASE Janssen Pharmaceutica, N.V. (BE) 2009-02-18 EP disclosed
WO-2007140005-A2 OXAZOLYL PIPERIDINE MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-12-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140370121-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF RPA1, RPA3, PCNA PDGFRB 3448/4885PDGFRA 2998/4885ALDH1A1 4306/4885
US-20130028989-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF RPA1, RPA3, PCNA PDGFRB 3448/4885PDGFRA 2998/4885ALDH1A1 4306/4885
US-20100292266-A1 Oxazolyl Piperidine Modulators of Fatty Acid Amide Hydrolase FAAH, FAAH2, APEH PDGFRB 1010/4885PDGFRA 770/4885ALDH1A1 635/4885
US-20170182055-A1 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF RPA1, PCNA, RPA3 PDGFRB 3574/4885PDGFRA 2971/4885ALDH1A1 4502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.