Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762014 | 0.87 | ALDH1A1 (0.44) | NLRP3HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL23601181 | 0.83 | ALDH1A1 (0.46) | HPGDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL24721757 | 0.81 | NLRP3 (0.40) | NLRP3ALDH1A1NOTUMKIF11SIGMAR1 | |
| SCHEMBL762346 | 0.78 | ALDH1A1 (0.55) | NLRP3HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL15591986 | 0.77 | NOTUM (0.41) | NLRP3HPGDALDH1A1NOTUMALOX15 | |
| SCHEMBL13763275 | 0.75 | LMNA (0.56) | ALDH1A1MAPTRAB9AHDAC6TP53 | |
| SCHEMBL17809604 | 0.75 | KDM1A (0.50) | NOTUMWDR5 | |
| SCHEMBL22005067 | 0.72 | NOTUM (0.50) | MEN1KMT2AALDH1A1NOTUMALOX15 | |
| SCHEMBL2616323 | 0.72 | ALDH1A1 (0.60) | HPGDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL13151196 | 0.71 | NLRP3 (0.42) | NLRP3HPGDMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |