Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 3/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007281 | 0.72 | TRPV4 (0.52) | TRPV4CYP3A4 | |
| SCHEMBL24056578 | 0.69 | AR (0.38) | ELANECYP11B1GRM1 | |
| SCHEMBL23613888 | 0.68 | CHRM4 (0.37) | USP30TRPV4 | |
| SCHEMBL24056594 | 0.67 | AR (0.37) | ELANECYP11B1 | |
| SCHEMBL24056591 | 0.67 | AR (0.40) | ELANECYP11B1 | |
| SCHEMBL24058142 | 0.65 | MAOA (0.42) | ELANECYP11B1 | |
| SCHEMBL24057981 | 0.65 | MAOA (0.39) | ELANECYP11B1 | |
| SCHEMBL23613926 | 0.64 | DDB1 (0.36) | CYP3A4KDM4E | |
| SCHEMBL6953445 | 0.62 | GRM5 (0.42) | CYP11B1CYP3A4CYP2D6 | |
| SCHEMBL7365422 | 0.62 | HPGD (0.40) | CYP11B1CYP3A4CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |