Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 3/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 7/20 | 0.49 |
| ▸ | CTSB | P07858 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSH | P09668 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23616270 | 0.88 | SMN1; SMN2 (0.50) | CTSLMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL19663542 | 0.82 | CAPN1 (0.58) | CAPN1ACECTSLCTSBMEN1 | |
| SCHEMBL8259852 | 0.82 | CTSB (0.62) | CTSLCTSBMEN1KMT2APSMB1 | |
| SCHEMBL23616285 | 0.82 | MME (0.55) | ACEMMP2MMP12MMP13 | |
| SCHEMBL23616375 | 0.82 | MMP3 (0.66) | CAPN1MMP1MMP2 | |
| SCHEMBL17238783 | 0.81 | CAPN1 (0.53) | CAPN1CTSLCTSBPSMB1PSMB5 | |
| SCHEMBL8436260 | 0.80 | ACE (0.73) | CAPN1ACECTSLMEN1HTT | |
| SCHEMBL22043608 | 0.79 | CTSB (0.57) | CAPN1CTSLCTSBPSMB1PSMB5 | |
| SCHEMBL20881480 | 0.79 | CTSB (0.57) | CAPN1CTSLCTSBPSMB1PSMB5 | |
| SCHEMBL24115066 | 0.79 | CTSB (0.57) | CAPN1CTSLCTSBPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297678-B1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LAURUS LABS LTD (IN) | 2021-07-07 | — | — | EP | disclosed |