Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21455194 | 0.87 | TBXAS1 (0.45) | TBXAS1PKMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL21455526 | 0.86 | TBXAS1 (0.44) | TBXAS1PKMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL23616699 | 0.84 | MAPK1 (0.33) | TBXAS1PKMMAPK1L3MBTL1 | |
| SCHEMBL23229153 | 0.80 | TBXAS1 (0.48) | TBXAS1PKMSMN1; SMN2CYP4F2CYP4A11 | |
| SCHEMBL23616967 | 0.79 | TBXAS1 (0.34) | TBXAS1PKMSMN1; SMN2 | |
| SCHEMBL23241666 | 0.79 | TBXAS1 (0.42) | TBXAS1PKMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL23617253 | 0.79 | TBXAS1 (0.47) | TBXAS1PKMSMN1; SMN2ALDH1A1CYP4F2 | |
| SCHEMBL7888801 | 0.78 | TBXAS1 (0.49) | TBXAS1PKMSMN1; SMN2ALDH1A1CYP4F2 | |
| SCHEMBL23616975 | 0.76 | ALDH1A1 (0.36) | TBXAS1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL23616962 | 0.76 | TBXAS1 (0.46) | TBXAS1PKMSMN1; SMN2ALDH1A1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687506-B1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARM INC (US) | 2021-07-07 | — | — | EP | disclosed |