Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20322398 | 0.87 | PLAU (0.53) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL29065120 | 0.84 | PLAU (0.59) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL26734673 | 0.84 | PLAU (0.59) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL20322393 | 0.82 | CTSL (0.52) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL21128024 | 0.81 | CTSL (0.54) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL2820683 | 0.81 | LMNA (0.61) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL5485588 | 0.81 | LMNA (0.61) | PLAULMNASMN1; SMN2CTSLCTSB | |
| Acetic Acid SCHEMBL8324881 | 0.80 | LMNA (0.56) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL21771638 | 0.78 | LMNA (0.62) | PLAULMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL1337448 | 0.78 | LMNA (0.58) | PLAULMNASMN1; SMN2CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558988-B1 | PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2021-07-07 | — | — | EP | disclosed |