Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820683 | 0.87 | LMNA (0.61) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| SCHEMBL5485588 | 0.87 | LMNA (0.61) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| SCHEMBL22580054 | 0.84 | LMNA (0.58) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| SCHEMBL21771638 | 0.84 | LMNA (0.62) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| SCHEMBL3254019 | 0.84 | LMNA (0.58) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| SCHEMBL6741072 | 0.83 | LMNA (0.65) | LMNASMN1; SMN2HTTALDH1A1CA12 | |
| SCHEMBL126974 | 0.83 | HTT (0.66) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| SCHEMBL11783251 | 0.83 | HTT (0.66) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| Hydrochloric Acid SCHEMBL8564606 | 0.83 | LMNA (0.56) | LMNASMN1; SMN2HTTPLAUALDH1A1 | |
| Acetic Acid SCHEMBL8324881 | 0.83 | LMNA (0.56) | LMNASMN1; SMN2HTTPLAUALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2020064175-A1 | INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION | ANTABIO SAS (FR) | 2020-04-02 | — | — | WO | disclosed |
| EP-3628672-A1 | INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION | Antabio SAS (FR) | 2020-04-01 | — | — | EP | disclosed |
| US-9920042-B2 | Compounds for use in the treatment of mycobacterial infections | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2018-03-20 | — | — | US | disclosed |
| EP-2900638-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 (FR) | 2017-01-04 | — | — | EP | disclosed |
| EP-2900638-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 (FR) | 2017-01-04 | — | — | EP | disclosed |
| US-20150225388-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2015-08-13 | — | — | US | disclosed |
| US-20150225388-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2015-08-13 | — | — | US | disclosed |
| EP-2900638-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | Université de Droit et de la Santé de Lille 2 (FR) | 2015-08-05 | — | — | EP | disclosed |
| US-8293752-B2 | Compounds useful as Raf kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20070112047-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-05-17 | — | — | US | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |
| US-20050038087-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2005-02-17 | — | — | US | disclosed |
| US-20040132788-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-07-08 | — | — | US | disclosed |
| EP-0149884-B1 | 5-PYRIDYL-1,3-THIAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4771054-A | QUINOLINE CARBOXYLIC ACID | WARNER-LAMBERT COMPANY (US) | 1988-09-13 | — | — | US | disclosed |
| EP-0106489-B1 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |
| EP-0201999-A1 | Substituted 2-cyano-2-oximino-acetamides, processes for their production and their use as fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-11-20 | — | — | EP | disclosed |
| US-4612321-A | 5-pyridyl-1,3-thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0149884-A2 | 5-Pyridyl-1,3-thiazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-07-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112047-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | LMNA 283/4885SMN1; SMN2 1999/4885HTT 3610/4885 |
| US-20050038087-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | OXER1, OPRL1, OPRK1 | LMNA 4096/4885SMN1; SMN2 687/4885HTT 122/4885 |
| US-20040132788-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | OPRK1, HCN1, P2RX7 | LMNA 3964/4885SMN1; SMN2 654/4885HTT 48/4885 |
| US-20150225388-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | C5, ALK, TYR | LMNA 1826/4885SMN1; SMN2 2371/4885HTT 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.