Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 16/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2361259 | 0.91 | PTGES (0.48) | PTGESJAK2CYP2C9CYP2D6TYK2 | |
| SCHEMBL2361393 | 0.81 | PTGES (0.47) | PTGESJAK2CYP2C9JAK3CYP2D6 | |
| SCHEMBL2361320 | 0.81 | PTGES (0.47) | PTGESJAK2CYP2C9 | |
| SCHEMBL2360992 | 0.81 | PTGES (0.59) | PTGESJAK2PIM1CSNK2A2CSNK2B | |
| SCHEMBL2336514 | 0.80 | PTGES (0.45) | PTGESJAK2CYP2C9CYP2D6 | |
| SCHEMBL2361712 | 0.80 | PTGES (0.50) | PTGESJAK2CYP2C9JAK3CYP2D6 | |
| SCHEMBL2360771 | 0.79 | PTGES (0.50) | PTGESJAK2TYK2 | |
| SCHEMBL2362143 | 0.78 | NPBWR1 (0.54) | — | |
| SCHEMBL2360991 | 0.78 | RHEB (0.52) | PTGESJAK2TYK2 | |
| SCHEMBL2361888 | 0.77 | AMY1A (0.47) | PTGESJAK2CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011099832-A2 | NOVEL BENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CRYSTALGENOMICS, INC. (KR) | 2011-08-18 | — | — | WO | disclosed |