SCHEMBL23620554

SCHEMBL23620554

COn1c(=O)[nH]c2cnc(Cl)nc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
PABPC1 P11940 1/20 0.44
KMT2A Q03164 1/20 0.44
TYRO3 Q06418 1/20 0.42
DYRK1B Q9Y463 1/20 0.42
CA9 Q16790 1/20 0.42
ADORA3 P0DMS8 1/20 0.37
KDM4E B2RXH2 3/20 0.34
IDH1 O75874 1/20 0.34
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
USP1 O94782 2/20 0.33
ALDH1A1 P00352 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PRKDC P78527 1/20 0.31
HAVCR2 Q8TDQ0 2/20 0.31
DRD1 P21728 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29864436 0.82 LMNA (0.60) MEN1LMNAPABPC1KMT2ATYRO3
SCHEMBL2265319 0.82 LMNA (0.60) MEN1LMNAPABPC1KMT2ATYRO3
SCHEMBL23948547 0.76 DAO (0.47) MEN1LMNAPABPC1KMT2ATYRO3
SCHEMBL1782345 0.75 USP1 (0.43) MEN1LMNAPABPC1KMT2ATYRO3
SCHEMBL20299431 0.73 PRKDC (0.46) PRKDC
SCHEMBL25057364 0.73 PRKDC (0.46) PRKDC
SCHEMBL23620391 0.73 PRKDC (0.46) PRKDC
SCHEMBL29502154 0.73 PRKDC (0.46) PRKDC
SCHEMBL29691179 0.72 KDM4E (0.54) MEN1KMT2AADORA3KDM4EUSP1
SCHEMBL18865652 0.72 KDM4E (0.54) MEN1KMT2AADORA3KDM4EUSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021136462-A1 FURAN DERIVATIVES AND APPLICATION THEREOF IN MEDICINE 成都百裕制药股份有限公司 2021-07-08 WO disclosed