Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264647 | 0.66 | DRD2 (0.36) | DRD2BACE1TRPA1 | |
| SCHEMBL4760147 | 0.66 | TRPA1 (0.36) | DRD2BACE1TRPA1 | |
| SCHEMBL407792 | 0.62 | DRD2 (0.33) | DRD2BACE1TRPA1 | |
| SCHEMBL2851413 | 0.59 | BACE1 (0.34) | DRD2BACE1TRPA1 | |
| SCHEMBL882180 | 0.59 | TRPA1 (0.36) | DRD2BACE1TRPA1 | |
| SCHEMBL2536697 | 0.59 | TRPA1 (0.36) | DRD2BACE1TRPA1 | |
| SCHEMBL21834864 | 0.59 | DRD2 (0.33) | DRD2BACE1TRPA1 | |
| SCHEMBL17103733 | 0.59 | TRPA1 (0.36) | DRD2BACE1TRPA1 | |
| SCHEMBL17865294 | 0.59 | BACE1 (0.39) | DRD2BACE1TRPA1 | |
| SCHEMBL21835118 | 0.58 | TRPA1 (0.35) | DRD2BACE1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358397-A2 | 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom | Isis Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010090969-A1 | TETRAHYDROPYRAN NUCLEIC ACID ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |
| WO-2010048549-A2 | 5' AND 2' BIS-SUBSTITUTED NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048552-A2 | METHODS OF USING OLIGOMERIC COMPOUNDS COMPRISING 2'-SUBSTITUTED NUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |