Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407792 | 0.67 | DRD2 (0.33) | BACE1DRD2TRPA1 | |
| SCHEMBL2362166 | 0.59 | DRD2 (0.35) | BACE1DRD2TRPA1 | |
| SCHEMBL4760147 | 0.57 | TRPA1 (0.36) | BACE1DRD2TRPA1 | |
| SCHEMBL4264647 | 0.57 | DRD2 (0.36) | BACE1DRD2TRPA1 | |
| SCHEMBL17865294 | 0.57 | BACE1 (0.39) | BACE1DRD2TRPA1 | |
| SCHEMBL117715 | 0.56 | TRPA1 (0.46) | BACE1DRD2TRPA1 | |
| SCHEMBL54919 | 0.56 | TRPA1 (0.45) | BACE1DRD2TRPA1 | |
| SCHEMBL29352703 | 0.56 | TRPA1 (0.45) | BACE1DRD2TRPA1 | |
| SCHEMBL24828 | 0.55 | TRPA1 (0.54) | BACE1DRD2TRPA1 | |
| SCHEMBL882180 | 0.54 | TRPA1 (0.36) | BACE1DRD2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851339-B1 | METHODS AND COMPOSITIONS FOR DETECTING A DRUG RESISTANT EGFR MUTANT | SLOAN KETTERING INST CANCER (US) | 2016-05-18 | — | — | EP | disclosed |
| US-8501413-B2 | Methods and compositions for detecting a drug resistant EGFR mutant | MEMORIAL-SLOAN KETTERING CANCER CENTER (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2505591-A1 | Methods and compositions for detecting a drug resistant EGFR mutant | Memorial Sloan-Kettering Cancer Center (US) | 2012-10-03 | — | — | EP | disclosed |
| US-20110319283-A1 | OLIGONUCLEOTIDES CAPABLE OF DISCRIMINATING BETWEEN NUCLEIC ACID SEQUENCES THAT COMPRISE A CONSERVED SEQUENCE | TRILLION GENOMICS LIMITED (GB) | 2011-12-29 | — | — | US | disclosed |
| US-20100173285-A1 | Methods and Compositions for Detecting a Drug Resistant Egfr Mutant | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2010-07-08 | — | — | US | disclosed |
| WO-2010058189-A1 | OLIGONUCLEOTIDES CAPABLE OF DISCRIMINATING BETWEEN NUCLEIC ACID SEQUENCES THAT COMPRISE A CONSERVED SEQUENCE | TRILLION GENOMICS LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |
| EP-1851339-A4 | METHODS AND COMPOSITIONS FOR DETECTING A DRUG RESISTANT EGFR MUTANT | SLOAN KETTERING INST CANCER (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080279920-A1 | Compositions For Treating Respiratory Viral Infections and Their Use | INTRADIGM CORPORATION (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080095747-A1 | Promotion of Cell Migration and Axon Regeneration in the Cns | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2008-04-24 | — | — | US | disclosed |
| EP-1851339-A2 | METHODS AND COMPOSITIONS FOR DETECTING A DRUG RESISTANT EGFR MUTANT | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1807539-A2 | EVALUATION OF THE TOXICITY OF PHARMACEUTICAL AGENTS | Novartis AG (CH) | 2007-07-18 | — | — | EP | disclosed |
| EP-1799272-A2 | PROMOTION OF CELL MIGRATION AND AXON REGENERATION IN THE CNS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20070065861-A1 | Methods for genetic analysis of alternative splicing | LEMISCHKA IHOR | 2007-03-22 | — | — | US | disclosed |
| US-20070065862-A1 | Methods for analysis of genetic interactions | BOARD OF TRUSTEES OF PRINCETON UNIVERSITY | 2007-03-22 | — | — | US | disclosed |
| WO-2006086777-A2 | METHODS AND COMPOSITIONS FOR DETECTING A DRUG RESISTANT EGFR MUTANT | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006050124-A2 | EVALUATION OF THE TOXICITY OF PHARMACEUTICAL AGENTS | NOVARTIS AG (CH) | 2006-05-11 | — | — | WO | disclosed |
| WO-2006042105-A2 | PROMOTION OF CELL MIGRATION AND AXON REGENERATION IN THE CNS | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2006-04-20 | — | — | WO | disclosed |
| US-6503754-B1 | A compound 8 to 50 nucleobases in length targeted to nucleobases 354 through 373 or nucleobases 707 through 726 of a coding region of a nucleic acid molecule encoding human BH3 Interacting domain Death agonist of SEQ ID NO: 3, nucleobases | ISIS PHARMACEUTICALS, INC. | 2003-01-07 | — | — | US | disclosed |