SCHEMBL2362279

SCHEMBL2362279

Cc1cc(F)c(Br)cc1CC(=O)NC1(C(=O)O)CCC2(CC1)OCC(C)O2

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 1/20 0.33
AKR1B1 P15121 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2355303 0.85 HCRTR2 (0.35) HCRTR2AKR1B1
SCHEMBL2362122 0.79 HCRTR2 (0.32) HCRTR2
SCHEMBL23326474 0.78 SHMT1 (0.37) AKR1B1
SCHEMBL2362284 0.77 ANO1 (0.32)
SCHEMBL21082992 0.70 NPC1 (0.39)
SCHEMBL248771 0.69 KDM4E (0.31)
SCHEMBL2350641 0.69 SCN9A (0.32)
SCHEMBL19838169 0.66 PYGL (0.33)
SCHEMBL19838175 0.65 SHMT1 (0.35)
SCHEMBL248156 0.65 RXRA (0.41) AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2536686-A1 CYCLIC KETO-ENOLS FOR THERAPY Bayer Intellectual Property GmbH (DE) 2012-12-26 EP disclosed
WO-2011098433-A1 CYCLIC KETO-ENOLS FOR THERAPY BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-08-18 WO disclosed