Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 4/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.52 |
| ▸ | HCN1 | O60741 | 1/20 | 0.51 |
| ▸ | F2R | P25116 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyl Alcohol SCHEMBL28866270 | 0.90 | F2R (0.48) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL13753068 | 0.84 | F2R (0.56) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL13753143 | 0.81 | HCRTR1 (0.57) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL23611756 | 0.80 | SMN1; SMN2 (0.55) | HCRTR1HPGDTP53GLAGAA | |
| SCHEMBL5525920 | 0.80 | CTSL (0.46) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL6273678 | 0.79 | CTSK (0.41) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL8317341 | 0.79 | KCNK3 (0.59) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL376957 | 0.79 | CTSD (0.62) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL29646406 | 0.79 | CTSD (0.62) | KCNK3KCNK9HCN1F2ROPRM1 | |
| SCHEMBL2307803 | 0.78 | KCNK3 (0.50) | KCNK3KCNK9HCN1F2ROPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025024543-A1 | TRICYCLIC UBE2K MODULATORS AND METHODS FOR THEIR USE | BPGBIO, INC. (US) | 2025-01-30 | — | — | WO | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |
| US-20220002255-A1 | UBE2K MODULATORS AND METHODS FOR THEIR USE | THLIVERIS, ANDREW T. | 2022-01-06 | — | — | US | disclosed |
| US-11091447-B2 | UBE2K modulators and methods for their use | BERG LLC (US) | 2021-08-17 | — | — | US | disclosed |
| US-20210214320-A1 | UBE2K MODULATORS AND METHODS FOR THEIR USE | THLIVERIS, ANDREW T. | 2021-07-15 | — | — | US | disclosed |
| WO-2021138540-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | BERG LLC (US) | 2021-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091447-B2 | UBE2K modulators and methods for their use | UBE2N, UBE2B, UBE2E1 | KCNK3 2414/4885KCNK9 2438/4885HCN1 4832/4885 |
| US-20220002255-A1 | UBE2K MODULATORS AND METHODS FOR THEIR USE | UBE2N, UBE2B, UBE2E1 | KCNK3 2414/4885KCNK9 2438/4885HCN1 4832/4885 |
| US-20210214320-A1 | UBE2K MODULATORS AND METHODS FOR THEIR USE | UBE2N, UBE2B, UBE2E1 | KCNK3 2414/4885KCNK9 2438/4885HCN1 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.