Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GCGR | P47871 | 8/20 | 0.49 |
| ▸ | GCG | P01275 | 4/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.48 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364553 | 0.84 | HPGD (0.44) | HPGDGCGCNR1NPC1RAB9A | |
| SCHEMBL2363580 | 0.80 | GCGR (0.58) | HPGDGCGRGCG | |
| SCHEMBL2363384 | 0.78 | GCGR (0.57) | GCGRGCG | |
| SCHEMBL2394244 | 0.76 | CSNK2A2 (0.47) | CNR1MEN1KMT2A | |
| SCHEMBL2364901 | 0.75 | GCGR (0.52) | HPGDGCGRGCGMEN1KMT2A | |
| SCHEMBL3200958 | 0.73 | AKR1B1 (0.58) | HPGDNPSR1 | |
| SCHEMBL2804428 | 0.72 | ATM (0.53) | HPGD | |
| SCHEMBL29415449 | 0.72 | ATM (0.53) | HPGD | |
| SCHEMBL10508515 | 0.71 | CNR1 (0.44) | HPGDCNR1MEN1KMT2A | |
| SCHEMBL13602497 | 0.71 | ATM (0.51) | HPGDNPC1RAB9ANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |