Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.58 |
| ▸ | GCG | P01275 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364901 | 0.93 | GCGR (0.52) | GCGRGCGHPGDHDAC3HDAC4 | |
| SCHEMBL2362953 | 0.80 | HPGD (0.52) | GCGRGCGHPGD | |
| SCHEMBL2363384 | 0.75 | GCGR (0.57) | GCGRGCG | |
| SCHEMBL14054246 | 0.74 | GCGR (1.00) | GCGR | |
| SCHEMBL3200958 | 0.73 | AKR1B1 (0.58) | HPGDATM | |
| SCHEMBL29415449 | 0.72 | ATM (0.53) | HPGDPTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL2804428 | 0.72 | ATM (0.53) | HPGDPTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL13602497 | 0.71 | ATM (0.51) | HPGDATM | |
| SCHEMBL9444876 | 0.70 | CCNC (0.52) | GCGRPTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL9288019 | 0.70 | TRPA1 (0.49) | PTGER1PTGER3PTGER2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |