Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xylene SCHEMBL2536913 | 0.88 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2HSD17B10LMNATSHR | |
| Benzoic Acid SCHEMBL27330443 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2SRD5A2HSD17B10LMNA | |
| Benzoic Acid SCHEMBL8413078 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2SRD5A2HSD17B10LMNA | |
| Ethyl Acetate SCHEMBL26103644 | 0.82 | NPC1 (0.56) | ALDH1A1SMN1; SMN2HSD17B10LMNATSHR | |
| Toluene SCHEMBL856707 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNATSHRKMT2A | |
| Toluene SCHEMBL510300 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNATSHRKMT2A | |
| Toluene SCHEMBL8554033 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNATSHRKMT2A | |
| Toluene SCHEMBL1996289 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNATSHRKMT2A | |
| Toluene SCHEMBL21490912 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNATSHRKMT2A | |
| Toluene SCHEMBL4248351 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10LMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111548269-B | Preparation method of diaryl methane structural compound | 兰州大学 | 2023-10-27 | — | — | CN | disclosed |
| CN-111662330-B | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2023-05-12 | — | — | CN | disclosed |
| US-20220401463-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | HELSINN HEALTHCARE SA (CH) | 2022-12-22 | — | — | US | disclosed |
| US-11312698-B2 | Fosnetupitant chloride hydrochloride having improved stability | HELSINN HEALTHCARE SA (CH) | 2022-04-26 | — | — | US | disclosed |
| CN-112979543-A | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-112961104-A | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2021-06-15 | — | — | CN | disclosed |
| US-20200399240-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | HELSINN HEALTHCARE SA (CH) | 2020-12-24 | — | — | US | disclosed |
| CN-111662330-A | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2020-09-15 | — | — | CN | disclosed |
| US-10717721-B2 | Substituted piperaziniums for the treatment of emesis | HELSINN HEALTHCARE SA (CH) | 2020-07-21 | — | — | US | disclosed |
| CN-106986822-B | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2020-04-21 | — | — | CN | disclosed |
| WO-2013082102-A1 | SUBSTITUTED 4 - PHENYL - PYRIDINES FOR THE TREATMENT OF NK-1 RECEPTOR RELATED DISEASES | HELSINN HEALTHCARE SA (CH) | 2013-06-06 | — | — | WO | disclosed |
| US-8426450-B1 | Substituted 4-phenyl pyridines having anti-emetic effect | HELSINN HEALTHCARE SA (CH) | 2013-04-23 | — | — | US | disclosed |
| CN-1176908-C | Process for producing pyridine derivate | - | 2004-11-24 | — | — | CN | disclosed |
| EP-1103546-B1 | Process for preparation of pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2003-10-22 | — | — | EP | disclosed |
| US-20020091265-A1 | 4-phenyl-pyridine derivatives | BOS MICHAEL (CA) | 2002-07-11 | — | — | US | disclosed |
| US-6303790-B1 | REACTING SUBSTITUTED NICOTINAMIDE WITH GRIGNARD REAGENT, OXIDIZING PRODUCT, REACTING WITH HALO-SUBSTITUTED AROMATIC COMPOUND | HOFFMAN-LA ROCHE INC. | 2001-10-16 | — | — | US | disclosed |
| US-6297375-B1 | 4-phenyl-pyridine derivatives | HOFFMANN-LA ROCHE INC. | 2001-10-02 | — | — | US | disclosed |
| CN-1297887-A | Process for producing pyridine derivate | HOFFMANN LA ROCHE (CH) | 2001-06-06 | — | — | CN | disclosed |
| EP-1103546-A1 | Process for preparation of pyridine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-05-30 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312698-B2 | Fosnetupitant chloride hydrochloride having improved stability | FOS, FOSB, CLCN2 | ALDH1A1 4187/4885SMN1; SMN2 1755/4885SRD5A2 4544/4885 |
| US-20200399240-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | BDKRB2, BDKRB1, TACR1 | ALDH1A1 1260/4885SMN1; SMN2 2452/4885SRD5A2 1775/4885 |
| US-20220401463-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | BDKRB2, BDKRB1, TACR1 | ALDH1A1 1260/4885SMN1; SMN2 2452/4885SRD5A2 1775/4885 |
| US-20020091265-A1 | 4-phenyl-pyridine derivatives | CBR1, CBR3, HCCS | ALDH1A1 1775/4885SMN1; SMN2 3866/4885SRD5A2 53/4885 |
| US-10717721-B2 | Substituted piperaziniums for the treatment of emesis | VIPR2, VIPR1, GRPR | ALDH1A1 1637/4885SMN1; SMN2 3111/4885SRD5A2 3623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.