Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12158567 | 0.77 | HSD11B1 (0.51) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1975025 | 0.74 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2321735 | 0.74 | HSD11B1 (0.59) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL23630293 | 0.73 | SSTR1 (0.40) | LMNAL3MBTL1ALDH1A1KMT2AHTT | |
| SCHEMBL75310 | 0.72 | TET3 (0.61) | HSD11B1HDAC4TET3KMT2AFBXL19 | |
| SCHEMBL2097060 | 0.72 | HSD11B1 (0.58) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL3554737 | 0.72 | HSD11B1 (0.58) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL20564856 | 0.72 | HDAC4 (0.47) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL15113219 | 0.71 | HDAC4 (0.54) | HSD11B1HDAC4LMNAALDH1A1 | |
| SCHEMBL12020371 | 0.71 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |