Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 4/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDE | P14735 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29943895 | 1.00 | AOC3 (0.40) | AOC3GRM5KLKB1KLK1SMARCA2 | |
| SCHEMBL23630479 | 0.88 | AOC3 (0.40) | AOC3GRM5KLKB1GPR52PIK3CA | |
| SCHEMBL29943898 | 0.88 | AOC3 (0.40) | AOC3GRM5KLKB1GPR52PIK3CA | |
| SCHEMBL29944108 | 0.81 | GABRP (0.45) | AOC3GRM5KLKB1GPR52PIK3CA | |
| SCHEMBL23630379 | 0.81 | GABRP (0.45) | AOC3GRM5KLKB1GPR52PIK3CA | |
| SCHEMBL23630466 | 0.81 | PIK3CA (0.47) | SMARCA2SMARCA4HTR4PIK3CAHRH3 | |
| SCHEMBL29944012 | 0.81 | PIK3CA (0.47) | SMARCA2SMARCA4HTR4PIK3CAHRH3 | |
| SCHEMBL23630514 | 0.78 | ALDH1A1 (0.46) | AOC3GRM5HRH3KMT2ASMN1; SMN2 | |
| SCHEMBL23630504 | 0.77 | AOC3 (0.60) | AOC3HRH3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL23630339 | 0.76 | AOC3 (0.59) | AOC3HRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2023-03-23 | — | — | US | disclosed |
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | VHL, SMARCC2, SMARCC1 | AOC3 4259/4885GRM5 4636/4885KLKB1 3725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.