Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ME2 | P23368 | 2/20 | 0.35 |
| ▸ | ME1 | P48163 | 2/20 | 0.35 |
| ▸ | ME3 | Q16798 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29943898 | 1.00 | AOC3 (0.40) | AOC3FFAR1ALDH1A1GRM5PLA2G10 | |
| SCHEMBL23630379 | 0.89 | GABRP (0.45) | AOC3GRM5GPR52KLKB1PIK3CA | |
| SCHEMBL29944108 | 0.89 | GABRP (0.45) | AOC3GRM5GPR52KLKB1PIK3CA | |
| SCHEMBL29943895 | 0.88 | AOC3 (0.40) | AOC3ALDH1A1GRM5GPR52KLKB1 | |
| SCHEMBL23630325 | 0.88 | AOC3 (0.40) | AOC3ALDH1A1GRM5GPR52KLKB1 | |
| SCHEMBL23630405 | 0.81 | PIK3CA (0.54) | ALDH1A1KDM4EHSD17B10PIK3CA | |
| SCHEMBL29943886 | 0.81 | PIK3CA (0.54) | ALDH1A1KDM4EHSD17B10PIK3CA | |
| SCHEMBL23630466 | 0.75 | PIK3CA (0.47) | ALDH1A1KDM4EHPGDPIK3CA | |
| SCHEMBL29944012 | 0.75 | PIK3CA (0.47) | ALDH1A1KDM4EHPGDPIK3CA | |
| SCHEMBL23630351 | 0.74 | PIK3CA (0.41) | ALDH1A1GRM5PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2023-03-23 | — | — | US | disclosed |
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | VHL, SMARCC2, SMARCC1 | AOC3 4259/4885FFAR1 4181/4885ALDH1A1 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.