Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.31 |
| ▸ | DPP4 | P27487 | 4/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.31 |
| ▸ | RRM1 | P23921 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228737 | 0.75 | CTSS (0.31) | CTSSCTSK | |
| SCHEMBL18228920 | 0.75 | CTSS (0.31) | CTSSCTSK | |
| SCHEMBL19899405 | 0.75 | CTSS (0.31) | CTSSCTSK | |
| SCHEMBL12290407 | 0.75 | FAAH (0.36) | SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL20591703 | 0.74 | CTSS (0.31) | CTSSCTSK | |
| Hydrochloric Acid SCHEMBL20591746 | 0.74 | CTSS (0.31) | CTSSCTSK | |
| Hydrochloric Acid SCHEMBL20591745 | 0.74 | CTSS (0.31) | CTSSCTSK | |
| Hydrochloric Acid SCHEMBL20591705 | 0.74 | CTSS (0.31) | CTSSCTSK | |
| Hydrochloric Acid SCHEMBL18228637 | 0.74 | CTSS (0.31) | CTSSCTSK | |
| SCHEMBL18923209 | 0.71 | CYP2D6 (0.39) | DPP7SLC15A1CA1CA2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059858-B2 | Difluoroketamide derivatives as HtrA1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2021-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059858-B2 | Difluoroketamide derivatives as HtrA1 inhibitors | HTRA1, HTR1A, HTR1E | DPP7 573/4885EPHX1 502/4885SLC15A1 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.